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Greene will join Neve Campbell, Courteney Cox and David Arquette in sequel. By Eric Ditzian Ashley Greene at the “New Moon” Photo: Lester Cohen/ WireImage After years spent as a supporting player in the “Twilight” universe, Ashley Greene might be poised for breakout star status in Hollywood. She recently wrapped a starring role in “The Apparition” opposite Sebastian Stan (“Gossip Girl”) and Tom Felton (“Harry Potter”), and now she’s looking to step into a lead part in “Scream 4.” Greene’s rep confirmed to MTV News that the 23-year-old actress has been offered the starring role, joining returning stars Neve Campbell, Courteney Cox and David Arquette. The news was first reported by The Hollywood Reporter. Greene would play Campbell’s cousin, who is being established as the franchise’s new heroine for both “Scream 4” and future installments of the horror series. Additionally, Lake Bell is said to be in negotiations for a starring role, while Hayden Panettiere (“Heroes”) and Rory Culkin (“Signs”) have been offered parts. Panettiere would play Greene’s best friend, and Culkin would play Greene’s love interest. With “Scream 4” coming more than a decade after its predecessor, Campbell originally bowed out of the production , declining to reprise her role as Sid, the unfortunate girl who’s always on the run from the Ghostface Killer. Campbell’s decision forced franchise creator Kevin Williamson to go back to the drawing board . But the actress eventually reconsidered, Wes Craven signed on to direct and the film will hit theaters in April 2011. “We have fun with the idea of endless sequels, or ‘sequelitis’ as Kevin calls it in the script,” Craven said recently of the upcoming movie. “Sid goes through these three horrendous things, and ‘Stab’ was based on those horrible things. And then they’ve been taken by a studio and run into the ground in a series of sequels. She has been off by herself and living her own life, and she’s even written a book that has gotten a lot of critical acclaim. She’s kind of put her life back together in the course of these 10 years. But, certainly, there would be no ‘Scream’ without Ghostface, so she has to confront him again, but now as a woman who has really come out the darkness of her past.” Check out everything we’ve got on For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com .

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‘Twilight’ Star Ashley Greene Offered Lead Role In ‘Scream 4’