Myasthenia gravis is an autoimmune channelopathy: it features antibodies directed against the body#39;s own proteins. While various similar diseases have been linked to immunologic cross-reaction with an infective agent, there is no known causative pathogen that could account for myasthenia. There is a slight genetic predisposition: particular HLA types seem to predispose for MG (B8 and DR3 with DR1 more specific for ocular myasthenia). Up to 75% of patients have an abnormality of the thymus; 2
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Myasthenia gravis Pathophysiology
