They say to write what you know. Unfortunately, in the case of screenwriter Will Reiser, what he knew was cancer. Six years ago, Reiser was diagnosed with cancer in his back, and — after surgery to remove the tumor — decided to handle the life-changing situation the only way he knew how: by finding the humor. Thus, 50/50 was born.
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Seth Rogen and Will Reiser on 50/50 and How Life Sometimes Needs a Rewrite