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David Letterman is taking his Top 10 Lists, his Stupid Human Tricks, his Stupid Pet Tricks and his unique sense of humor and packing it all up. The comedian is set to retire as host of The Late Show. In honor of this sentimental occasion, we've already run down 14 of the greatest guests in Letterman history – and now we're here with 37 of the most unforgettable moments in Letterman history. They run an impressive gamut, from the host chatting with Charlie Sheen about cocaine to issuing a heartfelt statement about a school shooting. As evidenced by the emotional tributes being paid his way, there will never be another David Letterman. These videos help explain why. 1. Charlie Sheen Talks Cocaine on The Late Show Charlie Sheen appears here on The Late Show with David Letterman… and talks in depth about crack cocaine. 2. Fired Anchor on Letterman A.J. Clemente appears here on The Late Show with David Letterman. Watch the host try to get the fired anchor his job back. 3. Ryan Lochte on Letterman Ryan Lochte on The Late Show With David Letterman. It’s pretty great. 4. Lindsay Lohan on Letterman Lindsay Lohan on The Late Show with David Letterman, April 9, 2013. 5. David Letterman Reacts to Tonight Show Shake-Up David Letterman has a lot to say about Jay Leno being replaced by Jimmy Fallon. A lot of funny stuff, that is. 6. Shia LaBeouf Late Show Interview Shia LaBeouf appears here on The Late Show with David Letterman and opens up about his feud with Alec Baldwin. View Slideshow

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37 Unforgettable Moments in David Letterman History